His skills as an orchestra musician have taken him around the United States and to more than a dozen countries with such orchestras as the Boston Symphony, the Boston Lyric Opera, the Boston Philharmonic, the Colorado, New Hampshire and Albany Symphony Orchestras, the International Symphony in Jerusalem, the Orquesta Sinfonica de Galicia in Spain, the Orquesta Sinfonica del Estado De Mexico, and the Orchestra Sinfonica di Milano in Italy where he met his wife Silva. In addition to Maestro Marin Alsop, a few of the noted conductors with whom Mr. Hernandez has worked are Yuri Temirkanov, Simon Rattle, Michael Tilson Thomas and Lorin Maazel.

When not on stage, Rene Hernandez can often be found in the kitchen preparing one of his delicious non-musical creations.